ChemicalBook > CAS DataBase List > 4,5-Dimethoxy-1-cyanobenzocyclobutane

4,5-Dimethoxy-1-cyanobenzocyclobutane

Product Name
4,5-Dimethoxy-1-cyanobenzocyclobutane
CAS No.
35202-54-1
Chemical Name
4,5-Dimethoxy-1-cyanobenzocyclobutane
Synonyms
4,5-Dimethoxy-1-benzocyclobutenecarbonitrile;4,5-dimethoxy-1,2-dihydrocyclobutabenzene-1-carbonitrile;3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-triene-7-carbonitrile;NSC 154410;Ivabradine Impurity 79;Ivabradine Impurity 89;5-Dimethoxy-1-cyanobenzocyclobutane;1-Cyano-4,5-dimethoxybenzocyclobutene;4,5-Dimethoxy-1-cyanobenzocyclobutane;4,5-Dimethoxy-1-benzocyclobutenecarbonitrile>
CBNumber
CB01503975
Molecular Formula
C11H11NO2
Formula Weight
189.21
MOL File
35202-54-1.mol
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4,5-Dimethoxy-1-cyanobenzocyclobutane Property

Melting point:
83-84 °C
Boiling point:
345.9±42.0 °C(Predicted)
Density 
1.18
vapor pressure 
0.004Pa at 25℃
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO, Methanol
form 
Solid
color 
Light Brown
LogP
1.22 at 30℃ and pH7
CAS DataBase Reference
35202-54-1(CAS DataBase Reference)
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Safety

HS Code 
2926907090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TCI Chemical
Product number
D4485
Product name
4,5-Dimethoxy-1-benzocyclobutenecarbonitrile
Purity
>98.0%(HPLC)(N)
Packaging
1g
Price
$124
Updated
2024/03/01
TCI Chemical
Product number
D4485
Product name
4,5-Dimethoxy-1-benzocyclobutenecarbonitrile
Purity
>98.0%(HPLC)(N)
Packaging
5g
Price
$438
Updated
2024/03/01
Medical Isotopes, Inc.
Product number
57314
Product name
4,5-Dimethoxy-1-benzocyclobutenecarbonitrile
Packaging
10g
Price
$1460
Updated
2021/12/16
AK Scientific
Product number
J98459
Product name
4,5-Dimethoxy-1-cyanobenzocyclobutane
Packaging
10g
Price
$140
Updated
2021/12/16
Chemenu
Product number
CM157211
Product name
4,5-Dimethoxy-1-cyanobenzocyclobutane
Purity
95%
Packaging
10g
Price
$143
Updated
2021/12/16
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4,5-Dimethoxy-1-cyanobenzocyclobutane Chemical Properties,Usage,Production

Uses

4,5-Dimethoxy-1-benzocyclobutenecarbonitrile is used in the preparation of selective bradycardic agents.

Uses

4,5-Dimethoxy-1-cyanobenzocyclobutane is used in the preparation of selective bradycardic agents.

Synthesis

NaNH2 (39.0 g, 1.0 mol) was added in portions to a solution of hydrocinnamonitrile 8 (224.0 g, 0.83 mol) in liquid ammonia at -45°C, and the reaction mixture was stirred at -45 °C for 2 h. After evaporation of the excess NH3, NH4Cl (20.0 g) and water (1000 mL) were added in portions. After standing at room temperature, greyish crystals separated and were collected and recrystallised with ethanol to give 4,5-Dimethoxy-1-cyanobenzocyclobutane as a colourless powder. Yield 116.5 g (74%).

4,5-Dimethoxy-1-cyanobenzocyclobutane Preparation Products And Raw materials

Raw materials

Preparation Products

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4,5-Dimethoxy-1-cyanobenzocyclobutane Suppliers

Americas 1 Belgium 1 Canada 2 China 202 Europe 1 Germany 2 India 19 Japan 3 Switzerland 1 United Kingdom 4 United States 21 Global 257
RR Scientific LLC
Tel
+86-13917743231
Email
sales@rrscientific.com
Country
United States
ProdList
878
Advantage
58
Standardpharm Co. Ltd.
Tel
86-714-3992388
Email
overseasales1@yongstandards.com
Country
United States
ProdList
14336
Advantage
58
Alchem Pharmtech,Inc.
Tel
8485655694
Email
sales@alchempharmtech.com
Country
United States
ProdList
63711
Advantage
58
Aladdin Scientific
Tel
+1-833-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57511
Advantage
58
Alfa Chemistry
Tel
Email
info@alfa-chemistry.com
Country
United States
ProdList
2344
Advantage
58
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View Lastest Price from 4,5-Dimethoxy-1-cyanobenzocyclobutane manufacturers

Hebei Yanxi Chemical Co., Ltd.
Product
4,5-Dimethoxy-1-cyanobenzocyclobutane 35202-54-1
Price
US $50.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
100000
Release date
2023-09-12
Weijer International Trade (Hebei) Co., Ltd.
Product
4,5-Dimethoxy-1-cyanobenzocyclobutane 35202-54-1
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 tons
Release date
2021-10-08
Hebei Shengyuan Jinlong Import and Export Co. LTD
Product
4,5-Dimethoxy-1-cyanobenzocyclobutane 35202-54-1
Price
US $10.00-5.00/kg
Min. Order
1kg
Purity
.99
Supply Ability
Monthly supply of 1 ton
Release date
2022-10-28

35202-54-1, 4,5-Dimethoxy-1-cyanobenzocyclobutaneRelated Search:

3-(3-Chloropropyl)-7,8-dimethoxy-2,3,4,5-tetrahydro-1H-3-benzazepin-2-one Ivabradine Impurity 70 Ethyl (3R)-piperidine-3-carboxylate 5-[(2R)-2-Aminopropyl]-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indole-7-carbonitrile (2R,3R)-2,3-dihydroxybutanedioate 4-Hydroxypiperidine (Z)-3-(3-chloropropyl)-7,8-diethyl-1H-benzo[d] azepin-2 (3H)-one (1S)-4,5-Dimethoxy-1-[(methylamino)methyl]benzocyclobutane hydrochloride Phthalic anhydride O-Phthalimide Dibutyl phthalate Dimethyldimethoxysilane (Trifluoromethoxy)benzene 1204612-29-2 3,4-dimethoxy-N-methylbenzamide 8-DeMethyl Ivabradine N-(2,2-dimethoxy-ethyl)-3,4-dimethoxyphenylacetamide Hydroxy Ivabradine (3,4-Dimethoxyphenyl)acetic acid

  • 3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-triene-7-carbonitrile
  • 4,5-Dimethoxy-1-benzocyclobutenecarbonitrile
  • 4,5-Dimethoxy-1-cyanobenzocyclobutane
  • Bicyclo[4.2.0]octa-1,3,5-triene-7-carbonitrile,3,4-diMethoxy-
  • 4,5-DiMethxoy-1,2-dihydrocyclobutabenzene-1-carbonitrile
  • 2-cyclobutyl-2-(3,4-diMethoxyphenyl)acetonitrile
  • 3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene-8-carbonitrile
  • 1,2-Dihydro-4,5-diMethoxybenzocyclobutene-1-carbonitrile
  • NSC 154410
  • 4,5-dimethoxy-1,2-dihydrocyclobutabenzene-1-carbonitrile
  • 1-Cyano-4,5-dimethoxybenzocyclobutene
  • 4,5-diMethoxy-1-cyanobenzocyclobutane (For Ivabradine)
  • Ivabradine Impurity 79
  • 5-Dimethoxy-1-cyanobenzocyclobutane
  • 4,5-Dimethoxy-1-benzocyclobutenecarbonitrile&gt
  • 4,5-Dimethoxy-1-cyanobenzocyclobutane CAS 35202-54-1
  • Ivabradine Impurity 89
  • 35202-54-1